Supported by the National Natural Science Foundation of China (Grant No. T2425021), a research team led by Professor Lingqian Chang from Beihang University, in collaboration with City University of Hong Kong, Peking University First Hospital, and the Cancer Hospital of the Chinese Academy of Medical Sciences, has made a significant advance in targeted drug and gene delivery to internal organs. The study, titled “An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery,” was published online in Cell on January 27, 2026 (https://doi.org/10.1016/j.cell.2025.12.021).

The complex and highly curved surfaces of internal organs, such as ovaries and kidneys, have posed a major challenge: existing flexible devices struggle to achieve both high conformality and sufficient functional coverage across the entire organ surface. To overcome this, the team established a universal conformality theory based on kirigami tessellation, which provided a general design framework for the development of a flexible bioelectronic patch named POCKET. This platform enables spatiotemporally controlled, efficient, and safe delivery of drugs or genes directly into target cells across the whole organ under low-voltage conditions. Its therapeutic efficacy has been demonstrated in animal models of hereditary ovarian cancer and renal ischemia‑reperfusion injury.

This work addresses critical theoretical and technical challenges in the interface matching between “hard” electronic devices and “soft” biological tissues. It establishes a therapeutic paradigm of “in situ organ‑specific intervention,” providing an innovative engineering solution for targeted treatment of organ‑specific diseases and translational medicine.

Fig. POCKET: An organ-customized electronic patch achieving spatiotemporally controlled precise drug delivery.